The
Hardy- Weinberg theorem:
In 1908, English mathematician Godfrey
H. Hardy and German physician Wilhelm Weinberg independently derived a
mathematical model describing what happens to the relative frequency of alleles
in a sexually reproducing population over time. Their combined ideas became
known as the Hardy-Weinberg Theorem. It states that the mixing of alleles at
meiosis and their subsequent recombination do not alter the relative
frequencies of the alleles in future generations, if certain assumptions are met. Stated another way, if certain
assumptions are met, evolution will not
occur because the relative allelic frequencies will not change from generation
to generation, even though the specific mixes of alleles in individuals may
vary.
The assumptions of he Theorem are:
1- Population size must be large. Large size
ensures that gene frequency will not change by chance alone.
2- Individuals cannot migrate into or out of the
population. Migration may introduce new alleles into the gene pool or add or
delete copies of existing alleles.
3- Mutations must not occur. If they do,
mutational equilibrium must exist. Mutational equilibrium exists when mutation
from the wild type allel to a mutant forn is balanced by the mutation from the
mutant form back to the wild type. In either case, no new genes are introduced
into the population from the sources.
4- Sexual reproduction within the population must
be random. Every individuals must have and equal chance of mating with any
other individuals in the population. If this condition is not fulfilled then
some individuals are more likely too reproduced than others, and natural
selection may occur.
These
assumptions must be met if allelic frequencies are not changing that is if
evolution is not occurring. Clearly, these assumptions are restrictive and few,
if any real population meet them. This mean that most population are
evolving.The Hard-Weinberg Theorem does provide a useful theoretical frame work
for examining changes in allelic frequencies in population.
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